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PIK3R1

Official Full Name
phosphoinositide-3-kinase regulatory subunit 1
Organism
Homo sapiens
GeneID
5295
Background
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Synonyms
p85; AGM7; GRB1; IMD36; p85alpha; p85-ALPHA;

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