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PHLPP1

Official Full Name
PH domain and leucine rich repeat protein phosphatase 1
Organism
Homo sapiens
GeneID
23239
Background
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Synonyms
SCOP; PHLPP; PPM3A; PLEKHE1;

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