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GRN


Official Full Name
granulin precursor
Organism
Homo sapiens
Gene ID
2896
Background
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Synonyms
GEP; FTD2; GP88; PEPI; PGRN; CLN11; PCDGF

Cat.No. Product Name Price
SHH308182 shRNA set against Human GRN (NM_002087.2) Inquiry
SHH308186 shRNA set against Rat GRN (NM_017113.2) Inquiry
Cat.No. Product Name Price
CDFH008077 Human GRN cDNA Clone(NM_002087.2) Inquiry
CDFH008078 Human GRN cDNA Clone(NM_002087.2) Inquiry
CDFL005367 Mouse Grn cDNA Clone(NM_008175.4) Inquiry
CDFR010163 Rat Grn cDNA Clone(NM_001145842.1) Inquiry
CDFR011168 Rat Grn cDNA Clone(NM_017113.2) Inquiry
MiUTR1H-04293 GRN miRNA 3'UTR clone Inquiry
SKO0503 GRN Validated sgRNA vector Inquiry
CDCB188152 Rabbit GRN ORF clone (XM_008271579.1) Inquiry
CDCL184476 Human GRN ORF clone(NM_002087.2) Inquiry
CDCL184477 Mouse GRN ORF clone(NM_008175.4) Inquiry
CDCR377394 Rat Grn ORF Clone(NM_001145842.1) Inquiry
CDCR378182 Rat Grn ORF Clone(NM_017113.2) Inquiry
CDCS410605 Human GRN ORF Clone (BC000324) Inquiry
CDCS410606 Human GRN ORF Clone (BC010577) Inquiry
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