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PDK3


Official Full Name
pyruvate dehydrogenase kinase 3
Organism
Homo sapiens
Gene ID
5165
Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Synonyms
CMTX6; GS1-358P8.4

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AD12039Z Human PDK3 adenoviral particles Inquiry
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SHH372888 shRNA set against Human PDK3 (NM_005391.4) Inquiry
SHH372892 shRNA set against Mouse PDK3 (NM_145630.2) Inquiry
SHH372896 shRNA set against Rat PDK3 (NM_001106581.1) Inquiry
SHR102768 shRNA set against Mouse Pdk3(NM_145630.2) Inquiry
SHW000348 shRNA set against Chicken PDK3 (NM_001006259) Inquiry
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CDFR006337 Rat Pdk3 cDNA Clone(NM_001106581.1) Inquiry
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MiUTR3H-05062 PDK3 miRNA 3'UTR clone Inquiry
CDCB161823 Chicken PDK3 ORF Clone (NM_001006259) Inquiry
CDCB186654 Rabbit PDK3 ORF clone (XM_002719989.2) Inquiry
CDCL147683 Mouse Pdk3 ORF clone (NM_145630.2) Inquiry
CDCL185681 Human PDK3 ORF clone(NM_005391.4) Inquiry
CDCR373364 Rat Pdk3 ORF Clone(NM_001106581.1) Inquiry
CDCS408261 Human PDK3 ORF Clone (BC015948) Inquiry
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