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PCSK7


Official Full Name
proprotein convertase subtilisin/kexin type 7
Organism
Homo sapiens
Gene ID
9159
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Synonyms
LPC; PC7; PC8; SPC7

Cat.No. Product Name Price
SHH372044 shRNA set against Human PCSK7 (NM_004716.2) Inquiry
SHH372048 shRNA set against Rat PCSK7 (NM_019246.1) Inquiry
SHR097904 shRNA set against Human PCSK7(NM_004716.2) Inquiry
SHR097922 shRNA set against Rat Pcsk7(NM_019246.1) Inquiry
SHR097950 shRNA set against Mouse Pcsk7(NM_008794.2) Inquiry
SHW001176 shRNA set against Chicken PCSK7 (NM_001030357) Inquiry
SHW011231 shRNA set against Danio rerio PCSK7 (NM_001083025) Inquiry
Cat.No. Product Name Price
CDCL185641 Human PCSK7 ORF clone(NM_004716.2) Inquiry
CDFH013865 Human PCSK7 cDNA Clone(NM_004716.2) Inquiry
CDFH013866 Human PCSK7 cDNA Clone(NM_004716.2) Inquiry
CDFR011539 Rat Pcsk7 cDNA Clone(NM_019246.1) Inquiry
MiUTR1H-07689 PCSK7 miRNA 3'UTR clone Inquiry
MiUTR1M-09017 PCSK7 miRNA 3'UTR clone Inquiry
MiUTR1R-05692 PCSK7 miRNA 3'UTR clone Inquiry
CDCB162651 Chicken PCSK7 ORF Clone (NM_001030357) Inquiry
CDCB172706 Danio rerio PCSK7 ORF Clone (NM_001083025) Inquiry
CDCB192237 Rabbit PCSK7 ORF clone (XM_002708370.2) Inquiry
CDCR246139 Mouse Pcsk7 ORF Clone(NM_008794.2) Inquiry
CDCR378542 Rat Pcsk7 ORF Clone(NM_019246.1) Inquiry
CDCS411927 Human PCSK7 ORF Clone (BC006357) Inquiry
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