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PAPPA


Official Full Name
pappalysin 1
Organism
Homo sapiens
Gene ID
5069
Background
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Synonyms
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase

Cat.No. Product Name Price
SHH370532 shRNA set against Mouse PAPPA (NM_021362.1) Inquiry
SHH370536 shRNA set against Rat PAPPA (NM_001107939.1) Inquiry
SHR078032 shRNA set against Mouse Pappa(NM_021362.1) Inquiry
SHR087468 shRNA set against Human PAPPA(NM_002581.3) Inquiry
Cat.No. Product Name Price
CDFH013681 Human PAPPA cDNA Clone(NM_002581.3) Inquiry
CDFH013682 Human PAPPA cDNA Clone(NM_002581.3) Inquiry
CDFL009887 Mouse Pappa cDNA Clone(NM_021362.1) Inquiry
CDFR007472 Rat Pappa cDNA Clone(NM_001107939.1) Inquiry
MiUTR1H-07497 PAPPA miRNA 3'UTR clone Inquiry
MiUTR1M-08890 PAPPA miRNA 3'UTR clone Inquiry
CDCB185152 Rabbit PAPPA ORF clone (XM_008273386.1) Inquiry
CDCL145889 Mouse Pappa ORF clone (NM_021362.1) Inquiry
CDCL145891 Human PAPPA ORF clone (NM_002581.3) Inquiry
CDCR374605 Rat Pappa ORF Clone(NM_001107939.1) Inquiry
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