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OLIG2

Official Full Name
oligodendrocyte transcription factor 2
Organism
Homo sapiens
GeneID
10215
Background
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Synonyms
BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19;

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