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OAZ2


Official Full Name
ornithine decarboxylase antizyme 2
Organism
Homo sapiens
Gene ID
4947
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Synonyms
AZ2

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SHR029094 shRNA set against Human OAZ2(NM_002537.2) Inquiry
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SHH357052 shRNA set against Mouse OAZ2 (NM_010952.3) Inquiry
SHR029328 shRNA set against Mouse Oaz2(NM_010952.3) Inquiry
SHW002842 shRNA set against Chicken OAZ2 (NM_001142862) Inquiry
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CDCB181253 Rabbit OAZ2 ORF clone (NM_001291912.1) Inquiry
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