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OXGR1


Official Full Name
oxoglutarate receptor 1
Organism
Homo sapiens
Gene ID
27199
Background
This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Synonyms
aKGR; CAON2; GPR80; GPR99; P2Y15; P2RY15

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SHH369344 shRNA set against Mouse OXGR1 (NM_001001490.3) Inquiry
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