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OAZ3


Official Full Name
ornithine decarboxylase antizyme 3
Organism
Homo sapiens
Gene ID
51686
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]
Synonyms
AZ3; OAZ-t; TISP15

Cat.No. Product Name Price
SHH357060 shRNA set against Human OAZ3 (NM_016178.2) Inquiry
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SHR029472 shRNA set against Mouse Oaz3(NM_016901.2) Inquiry
SHR029490 shRNA set against Human OAZ3(NM_016178.2) Inquiry
Cat.No. Product Name Price
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CDFG000205 Human OAZ3 cDNA Clone(NM_016178.2) Inquiry
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CDFL008714 Mouse Oaz3 cDNA Clone(NM_016901.2) Inquiry
MiUTR1H-07024 OAZ3 miRNA 3'UTR clone Inquiry
MiUTR1M-07935 OAZ3 miRNA 3'UTR clone Inquiry
CDCB181187 Rabbit OAZ3 ORF clone (NM_001291987.1) Inquiry
CDCR253256 Mouse Oaz3 ORF Clone(NM_016901.2) Inquiry
CDCR300599 Human OAZ3 ORF Clone(NM_016178.2) Inquiry
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