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oaz2b


Official Full Name
ornithine decarboxylase antizyme 2b
Organism
Danio rerio
Gene ID
790945
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. Several antizyme paralogs have been described in zebrafish. This gene encodes a novel antizyme, which is preferentially expressed in the retinal ganglion cell layer of the eye. [provided by RefSeq, Jan 2015]
Synonyms
AZR; oaz2l

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