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NXF1


Official Full Name
nuclear RNA export factor 1
Organism
Homo sapiens
Gene ID
10482
Background
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Synonyms
TAP; MEX67

Cat.No. Product Name Price
SHH356708 shRNA set against Mouse NXF1 (NM_016813.2) Inquiry
SHH356704 shRNA set against Human NXF1 (NM_006362.4) Inquiry
SHH356712 shRNA set against Rat NXF1 (NM_021579.1) Inquiry
SHR027808 shRNA set against Mouse Nxf1(NM_016813.2) Inquiry
SHR027826 shRNA set against Human NXF1(NM_001081491.1) Inquiry
SHR028038 shRNA set against Human NXF1(NM_006362.4) Inquiry
SHR028056 shRNA set against Human NXF1(NM_001081491.1) Inquiry
SHR028068 shRNA set against Rat Nxf1(NM_021579.1) Inquiry
Cat.No. Product Name Price
CDFH013011 Human NXF1 cDNA Clone(NM_001081491.1) Inquiry
CDFR011688 Rat Nxf1 cDNA Clone(NM_021579.1) Inquiry
MiUTR1H-07005 NXF1 miRNA 3'UTR clone Inquiry
MiUTR1H-07006 NXF1 miRNA 3'UTR clone Inquiry
MiUTR1M-07914 NXF1 miRNA 3'UTR clone Inquiry
MiUTR1R-04336 NXF1 miRNA 3'UTR clone Inquiry
CDCB189395 Rabbit NXF1 ORF clone (XM_002720996.2) Inquiry
CDCL140867 Human NXF1 ORF clone (NM_001081491.1) Inquiry
CDCL140871 Mouse Nxf1 ORF clone (NM_016813.2) Inquiry
CDCR292728 Human NXF1 ORF Clone(NM_006362.4) Inquiry
CDCR378735 Rat Nxf1 ORF Clone(NM_021579.1) Inquiry
CDCS407326 Human NXF1 ORF Clone (BC004904) Inquiry
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