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NUP98


Official Full Name
nucleoporin 98 and 96 precursor
Organism
Homo sapiens
Gene ID
4928
Background
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Synonyms
ADIR2; NUP96; NUP196; Nup98-96

Cat.No. Product Name Price
SHH356576 shRNA set against Human NUP98 (NM_005387.5) Inquiry
SHH356580 shRNA set against Mouse NUP98 (NM_022979.1) Inquiry
SHH356584 shRNA set against Rat NUP98 (NM_031074.2) Inquiry
SHR027320 shRNA set against Mouse Nup98(NM_022979.1) Inquiry
SHW016839 shRNA set against Danio rerio NUP98 (NM_200685) Inquiry
Cat.No. Product Name Price
CDCR317072 Human NUP98 ORF Clone(NM_139132.3) Inquiry
CDFR012546 Rat Nup98 cDNA Clone(NM_031074.2) Inquiry
MiUTR1M-07907 NUP98 miRNA 3'UTR clone Inquiry
MiUTR3H-03806 NUP98 miRNA 3'UTR clone Inquiry
MiUTR3H-03807 NUP98 miRNA 3'UTR clone Inquiry
MiUTR3H-03808 NUP98 miRNA 3'UTR clone Inquiry
MiUTR3H-03809 NUP98 miRNA 3'UTR clone Inquiry
CDCB178314 Danio rerio NUP98 ORF Clone (NM_200685) Inquiry
CDCB191551 Rabbit NUP98 ORF clone (XM_008264834.1) Inquiry
CDCL140801 Mouse Nup98 ORF clone (NM_022979.1) Inquiry
CDCR379568 Rat Nup98 ORF Clone(NM_031074.2) Inquiry
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