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NSD1


Official Full Name
nuclear receptor binding SET domain protein 1
Organism
Homo sapiens
Gene ID
64324
Background
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018]
Synonyms
STO; KMT3B; SOTOS; ARA267; SOTOS1

Cat.No. Product Name Price
SHH355316 shRNA set against Rat NSD1 (NM_001107337.1) Inquiry
SHH355312 shRNA set against Mouse NSD1 (NM_008739.3) Inquiry
SHH355308 shRNA set against Human NSD1 (NM_022455.4) Inquiry
Cat.No. Product Name Price
CDCR246038 Mouse Nsd1 ORF Clone(NM_008739.3) Inquiry
CDFL008580 Mouse Nsd1 cDNA Clone(NM_008739.3) Inquiry
CDFR006858 Rat Nsd1 cDNA Clone(NM_001107337.1) Inquiry
MiUTR1M-07838 NSD1 miRNA 3'UTR clone Inquiry
SKO0641 NSD1 Validated sgRNA vector Inquiry
CDCB184366 Rabbit NSD1 ORF clone (XM_008255460.1) Inquiry
CDCR321456 Human NSD1 ORF Clone(NM_172349.2) Inquiry
CDCR374050 Rat Nsd1 ORF Clone(NM_001107337.1) Inquiry
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