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Notum

Official Full Name
notum palmitoleoyl-protein carboxylesterase
Organism
Mus musculus
GeneID
77583
Background
Enables lipase activity; palmitoleyl hydrolase activity; and protein-containing complex destabilizing activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including foregut; genitourinary system; primitive streak; respiratory system; and sensory organ. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Notum; 5730593N15Rik;

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