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NOG


Official Full Name
noggin
Organism
Homo sapiens
Gene ID
9241
Background
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
Synonyms
SYM1; SYNS1; SYNS1A

Cat.No. Product Name Price
SHH353480 shRNA set against Mouse NOG (NM_008711.2) Inquiry
SHH353476 shRNA set against Human NOG (NM_005450.4) Inquiry
SHH353484 shRNA set against Rat NOG (NM_012990.1) Inquiry
SHR015068 shRNA set against Mouse Nog(NM_008711.2) Inquiry
SHR015234 shRNA set against Human NOG(NM_005450.4) Inquiry
SHW004642 shRNA set against Chicken NOG (NM_204123) Inquiry
Cat.No. Product Name Price
CDCL185500 Human Noggin ORF clone(NM_005450.4) Inquiry
CDCS412264 Human NOG ORF Clone (BC034027) Inquiry
CDFR010797 Rat Nog cDNA Clone(NM_012990.1) Inquiry
MiUTR1H-06833 NOG miRNA 3'UTR clone Inquiry
MiUTR1M-07727 NOG miRNA 3'UTR clone Inquiry
CDCB166117 Chicken NOG ORF Clone (NM_204123) Inquiry
CDCB181129 Rabbit NOG ORF clone (XM_002719279.2) Inquiry
CDCL185501 Mouse Noggin ORF clone(NM_008711.2) Inquiry
CDCR377834 Rat Nog ORF Clone(NM_012990.1) Inquiry
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