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NIPBL


Official Full Name
NIPBL cohesin loading factor
Organism
Homo sapiens
Gene ID
25836
Background
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CDLS; IDN3; Scc2; CDLS1; IDN3-B

Cat.No. Product Name Price
SHH352544 shRNA set against Human NIPBL (NM_015384.4) Inquiry
SHH352548 shRNA set against Mouse NIPBL (NM_201232.1) Inquiry
SHR003404 shRNA set against Mouse Nipbl(NM_201232.1) Inquiry
SHR003422 shRNA set against Mouse Nipbl(NM_027707.2) Inquiry
Cat.No. Product Name Price
CDFL008375 Mouse Nipbl cDNA Clone(NM_027707.2) Inquiry
CDFL008376 Mouse Nipbl cDNA Clone(NM_201232.1) Inquiry
MiUTR1M-07662 NIPBL miRNA 3'UTR clone Inquiry
MiUTR1M-07663 NIPBL miRNA 3'UTR clone Inquiry
MiUTR3H-10139 NIPBL miRNA 3'UTR clone Inquiry
MiUTR3H-10140 NIPBL miRNA 3'UTR clone Inquiry
CDCB185169 Rabbit NIPBL ORF clone (XM_008262124.1) Inquiry
CDCR260499 Mouse Nipbl ORF Clone(NM_027707.2) Inquiry
CDCR276929 Mouse Nipbl ORF Clone(NM_201232.1) Inquiry
CDCR299387 Human NIPBL ORF Clone(NM_015384.4) Inquiry
CDCS413950 Human NIPBL ORF Clone (BC033847) Inquiry
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