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NUB1


Official Full Name
negative regulator of ubiquitin like proteins 1
Organism
Homo sapiens
Gene ID
51667
Background
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Synonyms
BS4; NUB1L; NYREN18

Cat.No. Product Name Price
SHH355876 shRNA set against Human NUB1 (NM_016118.4) Inquiry
SHH355880 shRNA set against Mouse NUB1 (NM_016736.2) Inquiry
SHH355884 shRNA set against Rat NUB1 (NM_001013925.1) Inquiry
SHR025008 shRNA set against Mouse Nub1(NM_016736.2) Inquiry
SHW003831 shRNA set against Chicken NUB1 (NM_001277495) Inquiry
SHW012206 shRNA set against Danio rerio NUB1 (NM_001113580) Inquiry
Cat.No. Product Name Price
CDFR003003 Rat Nub1 cDNA Clone(NM_001013925.1) Inquiry
MiUTR1M-07867 NUB1 miRNA 3'UTR clone Inquiry
MiUTR1R-04310 NUB1 miRNA 3'UTR clone Inquiry
MiUTR3H-09629 NUB1 miRNA 3'UTR clone Inquiry
CDCB165306 Chicken NUB1 ORF Clone (NM_001277495) Inquiry
CDCB173681 Danio rerio NUB1 ORF Clone (NM_001113580) Inquiry
CDCB190032 Rabbit NUB1 ORF clone (XM_002715058.2) Inquiry
CDCL140429 Human NUB1 ORF clone (NM_001243351.1) Inquiry
CDCL140431 Human NUB1 ORF clone (NM_016118.4) Inquiry
CDCR252969 Mouse Nub1 ORF Clone(NM_016736.2) Inquiry
CDCR370081 Rat Nub1 ORF Clone(NM_001013925.1) Inquiry
CDCS409857 Human NUB1 ORF Clone (BC046354) Inquiry
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