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NR1I3


Official Full Name
nuclear receptor subfamily 1 group I member 3
Organism
Homo sapiens
Gene ID
9970
Background
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Synonyms
CAR; CAR1; MB67

Cat.No. Product Name Price
SHH354712 shRNA set against Human NR1I3 (NM_005122.4) Inquiry
SHH354716 shRNA set against Mouse NR1I3 (NM_009803.5) Inquiry
SHH354720 shRNA set against Rat NR1I3 (NM_022941.4) Inquiry
SHW005210 shRNA set against Chicken NR1I3 (NM_204702) Inquiry
Cat.No. Product Name Price
MiUTR3H-06348 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06346 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06345 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06344 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06343 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06342 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06341 NR1I3 miRNA 3'UTR clone Inquiry
MiUTR3H-06347 NR1I3 miRNA 3'UTR clone Inquiry
CDCS407225 Human NR1I3 ORF Clone (BC069626) Inquiry
CDCR345180 Human NR1I3 ORF Clone(NM_001077480.2) Inquiry
CDCH392229 Mouse NR1I3 ORF clone(NM_009803.5) Inquiry
CDCH392228 Mouse NR1I3 ORF clone(NM_001243063.1) Inquiry
CDCH392227 Mouse NR1I3 ORF clone(NM_001243062.1) Inquiry
CDCB190031 Rabbit NR1I3 ORF clone (XM_008264189.1) Inquiry
CDCB166685 Chicken NR1I3 ORF Clone (NM_204702) Inquiry
CDCR379211 Rat Nr1i3 ORF Clone(NM_022941.4) Inquiry
CDCB160241 Human NR1I3 ORF clone (NM_005122.3) Inquiry
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