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Nos1

Official Full Name
nitric oxide synthase 1, neuronal
Organism
Mus musculus
GeneID
18125
Background
Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Nos1; NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik;

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