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NLRP7

Official Full Name
NLR family, pyrin domain containing 7
Background
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
NLRP7; NLR family, pyrin domain containing 7; NACHT, leucine rich repeat and PYD containing 7 , NALP7; NACHT, LRR and PYD domains-containing protein 7; CLR19.4; NOD12; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; FLJ94610; HYDM; MGC126470; MGC126471; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains containing protein 7; NALP7; NALP7_HUMAN; Nucleotide-binding oligomerization domain protein 12; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PYRIN-containing APAF1-like protein 3

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