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NISCH


Official Full Name
nischarin
Organism
Homo sapiens
Gene ID
11188
Background
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Synonyms
I-1; IR1; IRAS; hIRAS

Cat.No. Product Name Price
SHH352584 shRNA set against Human NISCH (NM_007184.3) Inquiry
SHH352588 shRNA set against Mouse NISCH (NM_022656.2) Inquiry
SHR007782 shRNA set against Mouse Nisch(NM_022656.2) Inquiry
SHR007800 shRNA set against Human NISCH(NM_007184.3) Inquiry
Cat.No. Product Name Price
CDFL008380 Mouse Nisch cDNA Clone(NM_022656.2) Inquiry
MiUTR1H-06776 NISCH miRNA 3'UTR clone Inquiry
MiUTR1M-07666 NISCH miRNA 3'UTR clone Inquiry
CDCB189896 Rabbit NISCH ORF clone (XM_008260770.1) Inquiry
CDCL138429 Human Nisch ORF clone (NM_022656.2) Inquiry
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