Pages
Products

NF-KB


Official Full Name
nuclear factor kappa B subunit 1
Organism
Homo sapiens
Gene ID
4790
Background
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]
Synonyms
NFKB1; KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta

Cat.No. Product Name Price
AD10736Z Human NFKB1 adenoviral particles Inquiry
Cat.No. Product Name Price
RP00240 Recombinant Human NFKB1 (N-6His) Inquiry
Cat.No. Product Name Price
CDCS408789 Human NFKB1 ORF Clone (BC051765) Inquiry
CDFH012486 Human NFKB1 cDNA Clone(NM_001165412.1) Inquiry
MiUTR1H-06751 NFKB1 miRNA 3'UTR clone Inquiry
MiUTR1M-07634 NFKB1 miRNA 3'UTR clone Inquiry
MiUTR3H-01562 NFKB1 miRNA 3'UTR clone Inquiry
SKO0098 NFKB1 Validated sgRNA vector Inquiry
CDCB167109 Chicken NFKB1 ORF Clone (NM_205134) Inquiry
CDCB180625 Rabbit NFKB1 ORF clone (XM_008267557.1) Inquiry
CDCL138033 Human NFKB1 ORF clone (NM_003998.3) Inquiry
CDCL138039 Human Nfkb1 ORF clone (NM_008689.2) Inquiry
CDCL185473 Human NFkB1 ORF clone(NM_001165412.1) Inquiry
Cat.No. Product Name Price
CC-941 NFKB1 Easy KO Kit Inquiry
Quick Inquiry