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NCAM1


Official Full Name
neural cell adhesion molecule 1
Organism
Homo sapiens
Gene ID
4684
Background
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020]
Synonyms
CD56; NCAM; MSK39

Cat.No. Product Name Price
SHH217595 shRNA set against Mouse Ncam1(NM_001081445.1) Inquiry
SHR000084 shRNA set against Rat Ncam1(NM_031521.1) Inquiry
SHW002794 shRNA set against Chicken NCAM1 (NM_001128828) Inquiry
SHH349768 shRNA set against Human NCAM1 (NM_000615.6) Inquiry
SHH349772 shRNA set against Mouse NCAM1 (NM_010875.3) Inquiry
SHH349776 shRNA set against Rat NCAM1 (NM_031521.1) Inquiry
SHR000166 shRNA set against Mouse Ncam1(NM_010875.3) Inquiry
SHW003456 shRNA set against Chicken NCAM1 (NM_001242604) Inquiry
Cat.No. Product Name Price
CDCB188957 Rabbit NCAM1 ORF clone (XM_008261299.1) Inquiry
CDCL136739 Mouse Ncam1 ORF clone (NM_001081445.1) Inquiry
CDCL136747 Human NCAM1 ORF clone (NM_001242607.1) Inquiry
CDCL151438 Mouse Ncam1 ORF clone (NM_010875.3) Inquiry
CDCR337295 Human NCAM1 ORF Clone(NM_000615.6) Inquiry
CDCR344995 Human NCAM1 ORF Clone(NM_001076682.3) Inquiry
CDFR012681 Rat Ncam1 cDNA Clone(NM_031521.1) Inquiry
MiUTR1M-07517 NCAM1 miRNA 3'UTR clone Inquiry
MiUTR1M-07518 NCAM1 miRNA 3'UTR clone Inquiry
MiUTR1R-04128 NCAM1 miRNA 3'UTR clone Inquiry
CDCB164269 Chicken NCAM1 ORF Clone (NM_001128828) Inquiry
CDCB164931 Chicken NCAM1 ORF Clone (NM_001242604) Inquiry
CDCL136737 Mouse Ncam1 ORF clone (NM_001113204.1) Inquiry
CDCL136745 Human NCAM1 ORF clone (NM_001242608.1) Inquiry
CDCL185433 Rat NCAM1 ORF clone(NM_031521.1) Inquiry
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