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NALCN


Official Full Name
sodium leak channel, non-selective
Organism
Homo sapiens
Gene ID
259232
Background
This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
Synonyms
IHPRF; INNFD; CanIon; IHPRF1; VGCNL1; CLIFAHDD; bA430M15.1

Cat.No. Product Name Price
SHH349128 shRNA set against Human NALCN (NM_052867.2) Inquiry
SHH349132 shRNA set against Mouse NALCN (NM_177393.4) Inquiry
SHH349136 shRNA set against Rat NALCN (NM_153630.1) Inquiry
SHW008217 shRNA set against Danio rerio NALCN (NM_001017549) Inquiry
Cat.No. Product Name Price
CDCS416551 Human NALCN ORF Clone (BC064343) Inquiry
CDFL008139 Mouse Nalcn cDNA Clone(NM_177393.4) Inquiry
CDFR014617 Rat Nalcn cDNA Clone(NM_153630.1) Inquiry
MiUTR1H-11117 NALCN miRNA 3'UTR clone Inquiry
MiUTR1M-12680 NALCN miRNA 3'UTR clone Inquiry
MiUTR1R-08523 NALCN miRNA 3'UTR clone Inquiry
CDCB169692 Danio rerio NALCN ORF Clone (NM_001017549) Inquiry
CDCB182723 Rabbit NALCN ORF clone (XM_002713013.2) Inquiry
CDCL136419 Human NALCN ORF clone (NM_052867.2) Inquiry
CDCL136423 Human Nalcn ORF clone (NM_177393.4) Inquiry
CDCR381704 Rat Nalcn ORF Clone(NM_153630.1) Inquiry
CDCS416550 Human NALCN ORF Clone (BC028390) Inquiry
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