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MSR1


Official Full Name
macrophage scavenger receptor 1
Organism
Homo sapiens
Gene ID
4481
Background
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Synonyms
SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII

Cat.No. Product Name Price
SHH204115 shRNA set against Human MSR1(NM_138715.2) Inquiry
SHH345800 shRNA set against Mouse MSR1 (NM_031195.2) Inquiry
SHH204095 shRNA set against Mouse Msr1(NM_031195.2) Inquiry
SHH204097 shRNA set against Human MSR1(NM_002445.3) Inquiry
SHH204149 shRNA set against Human MSR1(NM_138716.2) Inquiry
SHH345796 shRNA set against Human MSR1 (NM_002445.3) Inquiry
Cat.No. Product Name Price
CDCL134663 Mouse Msr1 ORF clone (NM_031195.2) Inquiry
MiUTR1H-06482 MSR1 miRNA 3'UTR clone Inquiry
MiUTR1H-06483 MSR1 miRNA 3'UTR clone Inquiry
MiUTR1H-06484 MSR1 miRNA 3'UTR clone Inquiry
MiUTR1M-07340 MSR1 miRNA 3'UTR clone Inquiry
CDCB180503 Rabbit MSR1 ORF clone (NM_001082248.1) Inquiry
CDCL134659 Mouse MSR1 ORF clone (NM_138716.2) Inquiry
CDCL134665 Mouse Msr1 ORF clone (NM_001113326.1) Inquiry
CDCL185403 Rat MSR1 ORF clone(NM_001191939.1) Inquiry
CDCS416802 Human MSR1 ORF Clone (BC063878) Inquiry
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