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MMP2


Official Full Name
matrix metallopeptidase 2
Organism
Homo sapiens
Gene ID
4313
Background
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Synonyms
CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II

Cat.No. Product Name Price
SHH193665 shRNA set against Rat Mmp2(NM_031054.2) Inquiry
SHH193655 shRNA set against Mouse Mmp2(NM_008610.2) Inquiry
SHH193709 shRNA set against Human MMP2(NM_004530.4) Inquiry
SHH342988 shRNA set against Human MMP2 (NM_004530.4) Inquiry
SHH342992 shRNA set against Mouse MMP2 (NM_008610.2) Inquiry
SHH342996 shRNA set against Rat MMP2 (NM_031054.2) Inquiry
SHW004933 shRNA set against Chicken MMP2 (NM_204420) Inquiry
SHW015675 shRNA set against Danio rerio MMP2 (NM_198067) Inquiry
Cat.No. Product Name Price
CDCB177150 Danio rerio MMP2 ORF Clone (NM_198067) Inquiry
CDFH011593 Human MMP2 cDNA Clone(NM_001127891.1) Inquiry
CDFR012530 Rat Mmp2 cDNA Clone(NM_031054.2) Inquiry
MiUTR1H-06351 MMP2 miRNA 3'UTR clone Inquiry
MiUTR1M-07173 MMP2 miRNA 3'UTR clone Inquiry
MiUTR1R-03946 MMP2 miRNA 3'UTR clone Inquiry
MiUTR3H-00498 MMP2 miRNA 3'UTR clone Inquiry
CDCB166408 Chicken MMP2 ORF Clone (NM_204420) Inquiry
CDCB180234 Rabbit MMP2 ORF clone (NM_001082209.1) Inquiry
CDCL133193 Human MMP2 ORF clone (NM_001127891.1) Inquiry
CDCL133195 Mouse Mmp2 ORF clone (NM_008610.2) Inquiry
CDCR379552 Rat Mmp2 ORF Clone(NM_031054.2) Inquiry
CDCS407828 Human MMP2 ORF Clone (BC002576) Inquiry
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