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MKNK2


Official Full Name
MAPK interacting serine/threonine kinase 2
Organism
Homo sapiens
Gene ID
2872
Background
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Synonyms
MNK2; GPRK7

Cat.No. Product Name Price
SHH191261 shRNA set against Mouse Mknk2(NM_021462.3) Inquiry
SHH191279 shRNA set against Human MKNK2(NM_199054.2) Inquiry
SHH191297 shRNA set against Human MKNK2(NM_017572.3) Inquiry
SHH191315 shRNA set against Rat Mknk2(NM_001011985.1) Inquiry
SHH342316 shRNA set against Human MKNK2 (NM_017572.3) Inquiry
SHH342320 shRNA set against Mouse MKNK2 (NM_021462.3) Inquiry
SHH342324 shRNA set against Rat MKNK2 (NM_001011985.1) Inquiry
Cat.No. Product Name Price
CDCR255355 Mouse Mknk2 ORF Clone(NM_021462.3) Inquiry
CDFG000844 Human MKNK2 cDNA Clone(NM_017572.3) Inquiry
CDFR002415 Rat Mknk2 cDNA Clone(NM_001011985.1) Inquiry
MiUTR1H-06314 MKNK2 miRNA 3'UTR clone Inquiry
MiUTR1H-06315 MKNK2 miRNA 3'UTR clone Inquiry
MiUTR1M-07136 MKNK2 miRNA 3'UTR clone Inquiry
MiUTR1R-03931 MKNK2 miRNA 3'UTR clone Inquiry
CDCL132885 Human MKNK2 ORF clone (NM_017572.3) Inquiry
CDCR369502 Rat Mknk2 ORF Clone(NM_001011985.1) Inquiry
CDCS414421 Human MKNK2 ORF Clone (BC018345) Inquiry
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