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MPZ


Official Full Name
myelin protein zero
Organism
Homo sapiens
Gene ID
4359
Background
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
Synonyms
P0; CHM; DSS; MPP; CHN2; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB

Cat.No. Product Name Price
SHH344112 shRNA set against Rat MPZ (NM_017027.1) Inquiry
SHH197543 shRNA set against Mouse Mpz(NM_008623.4) Inquiry
SHH197561 shRNA set against Rat Mpz(NM_017027.1) Inquiry
SHH344108 shRNA set against Mouse MPZ (NM_008623.4) Inquiry
SHW015598 shRNA set against Danio rerio MPZ (NM_194361) Inquiry
Cat.No. Product Name Price
CDCS405723 Human MPZ ORF Clone (BC006491) Inquiry
CDFR011097 Rat Mpz cDNA Clone(NM_017027.1) Inquiry
MiUTR1M-07235 MPZ miRNA 3'UTR clone Inquiry
MiUTR1R-03970 MPZ miRNA 3'UTR clone Inquiry
CDCB159945 Human MPZ ORF clone (BC006491) Inquiry
CDCB177073 Danio rerio MPZ ORF Clone (NM_194361) Inquiry
CDCB193985 Rabbit MPZ ORF clone (XM_008264187.1) Inquiry
CDCR245842 Mouse Mpz ORF Clone(NM_008623.4) Inquiry
CDCR378140 Rat Mpz ORF Clone(NM_017027.1) Inquiry
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