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mcoln1a


Official Full Name
mucolipin TRP cation channel 1a
Organism
Danio rerio
Gene ID
406689
Background
Predicted to enable NAADP-sensitive calcium-release channel activity. Acts upstream of or within several processes, including neuromast hair cell development; regulation of late endosome to lysosome transport; and retina homeostasis. Located in late endosome and lysosome. Is expressed in several structures, including intermediate cell mass of mesoderm; nervous system; pleuroperitoneal region; yolk; and yolk syncytial layer. Used to study mucolipidosis type IV. Human ortholog(s) of this gene implicated in Lisch epithelial corneal dystrophy; glycoproteinosis; and mucolipidosis type IV. Orthologous to human MCOLN1 (mucolipin TRP cation channel 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
mcoln1; mcoln1.1; zgc:63619

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