MAZ

Official Full Name

MYC associated zinc finger protein

Organism

Homo sapiens

Gene ID

4150

Background

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801

Cat.No.	Product Name	Price
CSC-DC009264	Panoply™ Human MAZ Knockdown Stable Cell Line	Inquiry
CSC-SC009264	Panoply™ Human MAZ Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD09706Z	Human MAZ adenoviral particles	Inquiry
LV17859L	human MAZ (NM_001042539) lentivirus particles	Inquiry
LV17860L	human MAZ (NM_002383) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH179039	shRNA set against Mouse Maz(NM_010772.1)	Inquiry
SHH338715	shRNA set against Rat MAZ (NM_001110319.1)	Inquiry
SHH179021	shRNA set against Human MAZ(NM_001042539.1)	Inquiry
SHH179045	shRNA set against Human MAZ(NM_002383.2)	Inquiry
SHH338707	shRNA set against Human MAZ (NM_002383.2)	Inquiry
SHH338711	shRNA set against Mouse MAZ (NM_010772.1)	Inquiry

Cat.No.	Product Name	Price
CDCR376294	Rat Maz ORF Clone(NM_001110319.1)	Inquiry
CDFH011138	Human MAZ cDNA Clone(NM_001042539.1)	Inquiry
CDFH011139	Human MAZ cDNA Clone(NM_002383.2)	Inquiry
CDFL007418	Mouse Maz cDNA Clone(NM_010772.1)	Inquiry
CDFR009247	Rat Maz cDNA Clone(NM_001110319.1)	Inquiry
MiUTR1H-06125	MAZ miRNA 3'UTR clone	Inquiry
MiUTR1H-06126	MAZ miRNA 3'UTR clone	Inquiry
MiUTR1M-06974	MAZ miRNA 3'UTR clone	Inquiry
CDCB181007	Rabbit MAZ ORF clone (NM_001082041.1)	Inquiry
CDCL130971	Mouse MAZ ORF clone (NM_001042539.1)	Inquiry
CDCL130973	Human MAZ ORF clone (NM_002383.2)	Inquiry
CDCL130977	Mouse Maz ORF clone (NM_010772.1)	Inquiry

Detailed Information

Introduction

MAZ (MYC associated zinc finger protein) is a protein encoded by the MAZ gene in humans. MAZ gene is located in the 1-band and 2-subband (16.P11.2) of the long arm region of human autosomal 16. The MAZ gene transcript is 2.7 kb mRNA, encoding 477 amino acids and a MAZ protein with a molecular weight of approximately 60 kDa is obtained. MAZ protein plays a key role in the transcriptional initiation of certain target genes such as c-Myc and RAG-2. At the same time, MAZ protein also plays a role in the termination of transcription of some genes such as endothelial nitric oxide synthase (eNOS), Sp4, and telomerase. Therefore, MAZ is a transcription factor that has dual regulatory roles in initiating transcription of certain genes and terminating transcription of target genes.

MAZ Gene and Cancer

In recent years, studies have found that the expression of MAZ in many human malignant tumors is abnormally high, and is closely related to the occurrence and development of tumors. For example, the abnormal expression of MAZ in malignant glioma is higher than that in normal brain cells and astrocytes, and the expression of MAZ in malignant glioma stem cells is higher than that in malignant glioma, suggesting that MAZ may play the role of proto-oncogene in malignant glioma.

In addition, the expression of MAZ is abnormally elevated in liposarcoma, and it can cooperate with SPIN1, a histone-encoded reading gene, to co-enhance the expression of GDNF (glial cell-derived nutrient factor) in RET signaling pathway, thereby promoting the proliferation or reducing the apoptosis of liposarcoma cells. When the MAZ or SPIN1 gene is knocked down, the expression levels of GDNF and the activated RET protein are lowered, and the proliferation and survival of liposarcoma cells are also down-regulated.

It is well known that c-Myc gene is one of the important members of MYC gene family. The c-Myc gene is one of the most intensive proto-oncogenes and is closely related to hepatocarcinogenesis. Some scholars have found that P19 cells derived from neural ectoderm must have MAZ to activate the ME1a1-mediated expression of c-Myc gene. MAZ also plays a role in the distant metastasis of hepatocellular garcinoma (HCC) and the tumor-free survival time of postoperative patients.

MAZ can promote the expression of MCF-7 cells and enhance the invasion and metastasis ability of breast cancer cells. In addition, MAZ can bind to the pA1 sequence, thus specifically promoting the expression of PPAR-1 in breast cancer epithelial cells. In normal mammary epithelium, when the expression of MAZ gene is up-regulated, PPAR-1 expression can also be up-regulated, which promotes the occurrence of breast cancer.

References

1. Liu Wei, et al. Expression and significance of MAZ gene in hepatocellular carcinoma [J]. Journal of Clinical and Experimental Pathology, 2016, (6).

2. Liu Wei. The role and function of MAZ gene in hepatocellular carcinoma [D]. Guilin Medical College, 2016.

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