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TAB2


Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Organism
Homo sapiens
Gene ID
23118
Background
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Synonyms
CHTD2; TAB-2; MAP3K7IP2

Cat.No. Product Name Price
SHH337759 shRNA set against Rat MAP3K7IP2 (NM_001012062.1) Inquiry
SHH422364 shRNA set against Human TAB2 (NM_015093.4) Inquiry
SHH422368 shRNA set against Mouse TAB2 (NM_138667.3) Inquiry
SHW007864 shRNA set against Danio rerio TAB2 (NM_001009900) Inquiry
Cat.No. Product Name Price
CDFR002489 Rat Tab2 cDNA Clone(NM_001012062.1) Inquiry
MiUTR1R-03677 TAB2 miRNA 3'UTR clone Inquiry
MiUTR3H-07374 TAB2 miRNA 3'UTR clone Inquiry
CDCB169339 Danio rerio TAB2 ORF Clone (NM_001009900) Inquiry
CDCB192330 Rabbit TAB2 ORF clone (XM_008249910.1) Inquiry
CDCB196279 Rabbit LOC103350053 ORF clone (XM_008264425.1) Inquiry
CDCR369576 Rat Tab2 ORF Clone(NM_001012062.1) Inquiry
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