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MAP2K3


Official Full Name
mitogen-activated protein kinase kinase 3
Organism
Homo sapiens
Gene ID
5606
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Synonyms
MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2

Cat.No. Product Name Price
AD09614Z Human MAP2K3 adenoviral particles Inquiry
Cat.No. Product Name Price
SHH337551 shRNA set against Human MAP2K3 (NM_002756.4) Inquiry
SHH173449 shRNA set against Mouse Map2k3(NM_008928.4) Inquiry
SHH173495 shRNA set against Human MAP2K3(NM_145109.2) Inquiry
SHH337555 shRNA set against Mouse MAP2K3 (NM_008928.4) Inquiry
SHH337559 shRNA set against Rat MAP2K3 (NM_001100674.1) Inquiry
SHW000958 shRNA set against Chicken MAP2K3 (NM_001012787) Inquiry
Cat.No. Product Name Price
CDFL007339 Mouse Map2k3 cDNA Clone(NM_008928.4) Inquiry
CDFR005321 Rat Map2k3 cDNA Clone(NM_001100674.1) Inquiry
MiUTR1H-06054 MAP2K3 miRNA 3'UTR clone Inquiry
MiUTR1M-06909 MAP2K3 miRNA 3'UTR clone Inquiry
MiUTR3H-04864 MAP2K3 miRNA 3'UTR clone Inquiry
CDCB162433 Chicken MAP2K3 ORF Clone (NM_001012787) Inquiry
CDCB193668 Rabbit MAP2K3 ORF clone (XM_008252286.1) Inquiry
CDCR246352 Mouse Map2k3 ORF Clone(NM_008928.4) Inquiry
CDCR284006 Human MAP2K3 ORF Clone(NM_002756.4) Inquiry
CDCR372339 Rat Map2k3 ORF Clone(NM_001100674.1) Inquiry
CDCS410944 Human MAP2K3 ORF Clone (BC032478) Inquiry
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