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LRP2


Official Full Name
LDL receptor related protein 2
Organism
Homo sapiens
Gene ID
4036
Background
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Synonyms
DBS; GP330; LRP-2

Cat.No. Product Name Price
LV17319L human LRP2 (NM_004525) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH161183 shRNA set against Rat Lrp2(NM_030827.1) Inquiry
SHH161165 shRNA set against Human LRP2(NM_004525.2) Inquiry
SHH161201 shRNA set against Mouse Lrp2(NM_001081088.1) Inquiry
SHH334007 shRNA set against Human LRP2 (NM_004525.2) Inquiry
SHH334011 shRNA set against Mouse LRP2 (NM_001081088.1) Inquiry
SHH334015 shRNA set against Rat LRP2 (NM_030827.1) Inquiry
SHW013683 shRNA set against Danio rerio LRP2A (NM_001194987) Inquiry
Cat.No. Product Name Price
CDCB175158 Danio rerio LRP2A ORF Clone (NM_001194987) Inquiry
CDFR012359 Rat Lrp2 cDNA Clone(NM_030827.1) Inquiry
MiUTR1H-05899 LRP2 miRNA 3'UTR clone Inquiry
MiUTR1M-06747 LRP2 miRNA 3'UTR clone Inquiry
MiUTR1R-03558 LRP2 miRNA 3'UTR clone Inquiry
CDCB180372 Rabbit LRP2 ORF clone (XM_008258707.1) Inquiry
CDCB196700 Rabbit LOC103348064 ORF clone (XM_008255636.1) Inquiry
CDCB196701 Rabbit LOC103348059 ORF clone (XM_008255632.1) Inquiry
CDCH388055 Human LRP2 ORF clone(NM_004525.2) Inquiry
CDCH388056 Mouse LRP2 ORF clone(NM_001081088.1) Inquiry
CDCR379306 Rat Lrp2 ORF Clone(NM_030827.1) Inquiry
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