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LGMN


Official Full Name
legumain
Organism
Homo sapiens
Gene ID
5641
Background
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Synonyms
AEP; LGMN1; PRSC1

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SHW018665 shRNA set against Danio rerio LGMN (NM_214759) Inquiry
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SHH329931 shRNA set against Human LGMN (NM_005606.6) Inquiry
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Cat.No. Product Name Price
CDFR011911 Rat Lgmn cDNA Clone(NM_022226.2) Inquiry
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MiUTR1R-03000 LGMN miRNA 3'UTR clone Inquiry
MiUTR3H-05138 LGMN miRNA 3'UTR clone Inquiry
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CDCB159020 Human LGMN ORF clone (BC003061) Inquiry
CDCB180140 Danio rerio LGMN ORF Clone (NM_214759) Inquiry
CDCB189880 Rabbit LGMN ORF clone (XM_002719593.2) Inquiry
CDCL185151 Mouse LGMN ORF clone(NM_011175.2) Inquiry
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