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LGI1

Official Full Name
leucine rich glioma inactivated 1
Organism
Homo sapiens
GeneID
9211
Background
This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Synonyms
EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN;

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