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LARGE


Official Full Name
LARGE xylosyl- and glucuronyltransferase 1
Organism
Homo sapiens
Gene ID
9215
Background
This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]
Synonyms
LARGE1; LARGE; MDC1D; MDDGA6; MDDGB6

Cat.No. Product Name Price
SHH142319 shRNA set against Mouse Large(NM_010687.1) Inquiry
SHH328487 shRNA set against Human LARGE (NM_004737.4) Inquiry
SHH328491 shRNA set against Mouse LARGE (NM_010687.1) Inquiry
SHH328495 shRNA set against Rat LARGE (NM_001108439.1) Inquiry
SHW000144 shRNA set against Chicken LARGE (NM_001004383) Inquiry
SHW007147 shRNA set against Danio rerio LARGE (NM_001004537) Inquiry
Cat.No. Product Name Price
CDFR008053 Rat Large cDNA Clone(NM_001108439.1) Inquiry
MiUTR1M-06525 LARGE miRNA 3'UTR clone Inquiry
MiUTR3H-06095 LARGE miRNA 3'UTR clone Inquiry
MiUTR3H-06096 LARGE miRNA 3'UTR clone Inquiry
CDCB161619 Chicken LARGE ORF Clone (NM_001004383) Inquiry
CDCB168622 Danio rerio LARGE ORF Clone (NM_001004537) Inquiry
CDCB190193 Rabbit LARGE ORF clone (XM_008257097.1) Inquiry
CDCL126195 Human Large ORF clone (NM_010687.1) Inquiry
CDCR375094 Rat Large ORF Clone(NM_001108439.1) Inquiry
CDCS418889 Human LARGE ORF Clone (BC117425) Inquiry
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