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LIMK2


Official Full Name
LIM domain kinase 2
Organism
Homo sapiens
Gene ID
3985
Background
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Cat.No. Product Name Price
AD09191Z Human LIMK2 adenoviral particles Inquiry
Cat.No. Product Name Price
SHH150185 shRNA set against Human LIMK2(NM_016733.2) Inquiry
SHH330419 shRNA set against Human LIMK2 (NM_005569.3) Inquiry
SHH150095 shRNA set against Human LIMK2(NM_005569.3) Inquiry
SHH150113 shRNA set against Rat Limk2(NM_024135.2) Inquiry
SHH150131 shRNA set against Mouse Limk2(NM_010718.3) Inquiry
SHH150149 shRNA set against Mouse Limk2(NM_173053.1) Inquiry
SHH150167 shRNA set against Human LIMK2(NM_001031801.1) Inquiry
SHH150203 shRNA set against Mouse Limk2(NM_001034030.1) Inquiry
SHH330423 shRNA set against Mouse LIMK2 (NM_010718.3) Inquiry
SHH330427 shRNA set against Rat LIMK2 (NM_024135.2) Inquiry
SHW005615 shRNA set against Chicken LIMK2 (NM_205115) Inquiry
SHW006647 shRNA set against Danio rerio LIMK2 (NM_001002651) Inquiry
Cat.No. Product Name Price
CDFG000522 Human LIMK2 cDNA Clone(NM_016733.2) Inquiry
MiUTR1M-06653 LIMK2 miRNA 3'UTR clone Inquiry
MiUTR1M-06652 LIMK2 miRNA 3'UTR clone Inquiry
MiUTR1H-05689 LIMK2 miRNA 3'UTR clone Inquiry
MiUTR1H-05688 LIMK2 miRNA 3'UTR clone Inquiry
MiUTR1H-05687 LIMK2 miRNA 3'UTR clone Inquiry
CDFR012265 Rat Limk2 cDNA Clone(NM_024135.2) Inquiry
CDFH010408 Human LIMK2 cDNA Clone(NM_005569.3) Inquiry
CDFH010407 Human LIMK2 cDNA Clone(NM_005569.3) Inquiry
CDFH010406 Human LIMK2 cDNA Clone(NM_001031801.1) Inquiry
CDFG000524 Human LIMK2 cDNA Clone(NM_016733.2) Inquiry
MiUTR1R-03021 LIMK2 miRNA 3'UTR clone Inquiry
CDCR301634 Human LIMK2 ORF Clone(NM_016733.2) Inquiry
CDCL185167 Human LIMK2 ORF clone(NM_005569.3) Inquiry
MiUTR1M-06654 LIMK2 miRNA 3'UTR clone Inquiry
CDCS406773 Human LIMK2 ORF Clone (BC013051) Inquiry
CDCR379342 Rat Limk2 ORF Clone(NM_024135.2) Inquiry
CDCR342900 Human LIMK2 ORF Clone(NM_001031801.1) Inquiry
CDCL185168 Mouse LIMK2 ORF clone(NM_010718.3) Inquiry
CDCL127333 Human Limk2 ORF clone (NM_001034030.1) Inquiry
CDCL127331 Mouse Limk2 ORF clone (NM_173053.1) Inquiry
CDCB183816 Rabbit LIMK2 ORF clone (XM_008272149.1) Inquiry
CDCB168122 Danio rerio LIMK2 ORF Clone (NM_001002651) Inquiry
CDCB167090 Chicken LIMK2 ORF Clone (NM_205115) Inquiry
Cat.No. Product Name Price
CC-785 LIMK2 Easy KO Kit Inquiry
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