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LARS

Official Full Name
leucyl-tRNA synthetase 1
Organism
Homo sapiens
GeneID
51520
Background
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
Synonyms
LARS1; LRS; LARS; LEUS; LFIS; cLRS; ILFS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl;

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