LAMC3

Official Full Name

laminin subunit gamma 3

Organism

Homo sapiens

Gene ID

10319

Background

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]

Synonyms

OCCM

Cat.No.	Product Name	Price
CSC-DC008530	Panoply™ Human LAMC3 Knockdown Stable Cell Line	Inquiry
CSC-SC008530	Panoply™ Human LAMC3 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD09000Z	Human Lamc3 adenoviral particles	Inquiry
LV16742L	human LAMC3 (NM_006059) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH141725	shRNA set against Mouse Lamc3(NM_011836.3)	Inquiry
SHH141743	shRNA set against Human LAMC3(NM_006059.3)	Inquiry
SHH328323	shRNA set against Human Lamc3 (NM_006059.3)	Inquiry
SHH328327	shRNA set against Mouse Lamc3 (NM_011836.3)	Inquiry
SHH328331	shRNA set against Rat Lamc3 (NM_001107830.1)	Inquiry

Cat.No.	Product Name	Price
CDFR007459	Rat Lamc3 cDNA Clone(NM_001107830.1)	Inquiry
MiUTR1H-05566	LAMC3 miRNA 3'UTR clone	Inquiry
MiUTR1M-06517	LAMC3 miRNA 3'UTR clone	Inquiry
CDCB182226	Rabbit LAMC3 ORF clone (XM_008249050.1)	Inquiry
CDCL126121	Human LAMC3 ORF clone (NM_006059.3)	Inquiry
CDCL126123	Mouse Lamc3 ORF clone (NM_011836.3)	Inquiry
CDCR374505	Rat Lamc3 ORF Clone(NM_001107830.1)	Inquiry

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