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Krt2-5

Official Full Name
keratin 5
Organism
Mus musculus
GeneID
110308
Background
Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Involved in several processes, including intermediate filament polymerization; regulation of cell migration; and response to mechanical stimulus. Located in cytoplasm; keratin filament; and plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; epithelium; genitourinary system; integumental system; and sensory organ. Used to study epidermolysis bullosa simplex Dowling-Meara type. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Krt5; K5; CK5; Tfip8; Krt2-5; 3300001P10Rik;

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