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Krt1-18


Official Full Name
keratin 18
Organism
Mus musculus
Gene ID
16668
Background
Predicted to enable scaffold protein binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; and tumor necrosis factor-mediated signaling pathway. Located in cell periphery and keratin filament. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Krt18; K18; CK18; Krt1-18

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