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KPNB1


Official Full Name
karyopherin subunit beta 1
Organism
Homo sapiens
Gene ID
3837
Background
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Synonyms
IMB1; IPO1; IPOB; Impnb; NTF97

Cat.No. Product Name Price
SHH327063 shRNA set against Human KPNB1 (NM_002265.4) Inquiry
SHH327067 shRNA set against Mouse KPNB1 (NM_008379.3) Inquiry
SHH327071 shRNA set against Rat KPNB1 (NM_017063.1) Inquiry
SHL204420 shRNA set against Mouse Kpnb1(NM_008379.3) Inquiry
SHL204438 shRNA set against Rat Kpnb1(NM_017063.1) Inquiry
SHL204456 shRNA set against Human KPNB1(NM_002265.4) Inquiry
SHW009480 shRNA set against Danio rerio KPNB1 (NM_001037702) Inquiry
Cat.No. Product Name Price
CDCB170955 Danio rerio KPNB1 ORF Clone (NM_001037702) Inquiry
CDCL125313 Mouse Kpnb1 ORF clone (NM_008379.3) Inquiry
CDFH010066 Human KPNB1 cDNA Clone(NM_002265.4) Inquiry
CDFR011130 Rat Kpnb1 cDNA Clone(NM_017063.1) Inquiry
MiUTR1H-05427 KPNB1 miRNA 3'UTR clone Inquiry
MiUTR1M-06427 KPNB1 miRNA 3'UTR clone Inquiry
MiUTR1R-02927 KPNB1 miRNA 3'UTR clone Inquiry
CDCB185890 Rabbit KPNB1 ORF clone (XM_008271382.1) Inquiry
CDCR282832 Human KPNB1 ORF Clone(NM_002265.4) Inquiry
CDCR378163 Rat Kpnb1 ORF Clone(NM_017063.1) Inquiry
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