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KIFAP3


Official Full Name
kinesin associated protein 3
Organism
Homo sapiens
Gene ID
22920
Background
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Synonyms
FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1

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SHH325415 shRNA set against Human KIFAP3 (NM_014970.3) Inquiry
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SHH325423 shRNA set against Rat KIFAP3 (NM_001105964.1) Inquiry
SHL197454 shRNA set against Mouse Kifap3(NM_010629.2) Inquiry
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CDFR005738 Rat Kifap3 cDNA Clone(NM_001105964.1) Inquiry
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CDCL124333 Human KIFAP3 ORF clone (NM_001204514.1) Inquiry
CDCL124335 Human KIFAP3 ORF clone (NM_001204516.1) Inquiry
CDCL124337 Human KIFAP3 ORF clone (NM_001204517.1) Inquiry
CDCR249335 Mouse Kifap3 ORF Clone(NM_010629.2) Inquiry
CDCR298647 Human KIFAP3 ORF Clone(NM_014970.3) Inquiry
CDCR372767 Rat Kifap3 ORF Clone(NM_001105964.1) Inquiry
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