KATNB1

Official Full Name

katanin regulatory subunit B1

Organism

Homo sapiens

Gene ID

10300

Background

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Synonyms

KAT; LIS6

Cat.No.	Product Name	Price
CSC-DC007903	Panoply™ Human KATNB1 Knockdown Stable Cell Line	Inquiry
CSC-SC007903	Panoply™ Human KATNB1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD08360Z	Human KATNB1 adenoviral particles	Inquiry
LV15887L	human KATNB1 (NM_005886) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH322499	shRNA set against Human KATNB1 (NM_005886.2)	Inquiry
SHH322503	shRNA set against Mouse KATNB1 (NM_028805.2)	Inquiry
SHH322507	shRNA set against Rat KATNB1 (NM_001024746.1)	Inquiry
SHL187632	shRNA set against Human KATNB1(NM_005886.2)	Inquiry
SHL187650	shRNA set against Rat Katnb1(NM_001024746.1)	Inquiry
SHL187686	shRNA set against Mouse Katnb1(NM_028805.2)	Inquiry
SHW001215	shRNA set against Chicken KATNB1 (NM_001030559)	Inquiry
SHW018144	shRNA set against Danio rerio KATNB1 (NM_213018)	Inquiry

Cat.No.	Product Name	Price
CDFH009574	Human KATNB1 cDNA Clone(NM_005886.2)	Inquiry
CDFR003650	Rat Katnb1 cDNA Clone(NM_001024746.1)	Inquiry
MiUTR1H-05086	KATNB1 miRNA 3'UTR clone	Inquiry
MiUTR1M-06195	KATNB1 miRNA 3'UTR clone	Inquiry
MiUTR1R-02766	KATNB1 miRNA 3'UTR clone	Inquiry
CDCB162690	Chicken KATNB1 ORF Clone (NM_001030559)	Inquiry
CDCB179619	Danio rerio KATNB1 ORF Clone (NM_213018)	Inquiry
CDCB189638	Rabbit KATNB1 ORF clone (XM_002711544.2)	Inquiry
CDCR261415	Mouse Katnb1 ORF Clone(NM_028805.2)	Inquiry
CDCR291532	Human KATNB1 ORF Clone(NM_005886.2)	Inquiry
CDCR370691	Rat Katnb1 ORF Clone(NM_001024746.1)	Inquiry
CDCS412471	Human KATNB1 ORF Clone (BC001353)	Inquiry

Detailed Information

Recent Research

The microtubule-severing protein complex katanin is composed two subunits, the ATPase subunit, p60/KATNA1, and the noncatalytic regulatory subunit, p80/KATNB1. In developing neurons, Katanin localizes to microtubules and centrosomes and is essential for microtubule shortening and release.KATNA1 is a member of the AAA (ATPases Associated with diverse cellular Activities) domain containing protein family, whereasKATNB1 binds to p60 and targets it to subcellular structures including the centrosome, further mediating its interactions with Dynein, LIS1, and NDEL1. It is reported that KATNB1 is linked to infertility, regulation of centriole and cilia formation in ﬁsh and mammals, as well as neocortical brain development. KATNB1 is ubiquitously expressed during embryonic development, including germ cells in humans and mouse, mitotic/meiotic spindles and cilia. Furthermore, null and hypomorphic KATNB1 gene mutations show a novel correlation between KATNB1 dysregulation and the development of impaired left–right signaling, including cardiac malformations.

Some reports have shown that loss of KATNB1 orthologs in zebrafish and flies results in microcephaly, recapitulating the human phenotype. In the developing Drosophila optic lobe, KATNB1 loss specifically affects the asymmetrically dividing neuroblasts, which display supernumerary centrosomes and spindle abnormalities during mitosis, leading to cell cycle progression delays and reduced cell numbers. Furthermore, KATNB1depletion results in dendritic arborization defects in sensory and motor neurons, affecting neural architecture. And a missense mutation in the highly conserved WD40 domain of KATNB1 has been shown to cause azoospermia and male sterility in mice.

It has been found that deleterious mutations in KATNB1 that result in a spectrum of cerebral cortical development (MCD) disorders, including microcephaly co-occurring with lissencephaly or less severe neuronal migration abnormalities such as periventricular or subcortical heterotopias. In addition, recent research has shown that KATNB1 plays a role in human spermatogenesis and the genetic variants in KATNB1 are associated with oligoasthenoteratozoospermia (OAT) in humans. KATNB1 was present during spermatid development, and in particular localized to the microtubules of the manchette, a structure required for sperm head shaping.

References:

O'Donnell L, et al. KATNB1 in the human testis and its genetic variants in fertile and oligoasthenoteratozoospermic infertile men. Andrology, 2015, 2(6):884-891.
Furtado M B, et al. Mutations in the Katnb1 gene cause left‐right asymmetry and heart defects. Dev Dyn, 2017, 246(12).
Mishra-Gorur K, et al. Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors. Neuron, 2014, 84(6):1226-1239.

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