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KPNA2


Official Full Name
karyopherin subunit alpha 2
Organism
Homo sapiens
Gene ID
3838
Background
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Synonyms
QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha

Cat.No. Product Name Price
SHH326999 shRNA set against Human KPNA2 (NM_002266.2) Inquiry
SHH327007 shRNA set against Rat KPNA2 (NM_053483.2) Inquiry
SHL204726 shRNA set against Mouse Kpna2(NM_010655.3) Inquiry
SHL204858 shRNA set against Human KPNA2(NM_002266.2) Inquiry
SHW000300 shRNA set against Chicken KPNA2 (NM_001006209) Inquiry
SHW006370 shRNA set against Danio rerio KPNA2 (NM_001002335) Inquiry
Cat.No. Product Name Price
CDFH010059 Human KPNA2 cDNA Clone(NM_002266.2) Inquiry
MiUTR1H-05423 KPNA2 miRNA 3'UTR clone Inquiry
MiUTR1M-06425 KPNA2 miRNA 3'UTR clone Inquiry
CDCB156047 Rat KPNA2 ORF clone (BC062026.1) Inquiry
CDCB159092 Human KPNA2 ORF clone (BC005978) Inquiry
CDCB161775 Chicken KPNA2 ORF Clone (NM_001006209) Inquiry
CDCB167845 Danio rerio KPNA2 ORF Clone (NM_001002335) Inquiry
CDCB186758 Rabbit KPNA2 ORF clone (XM_008271722.1) Inquiry
CDCL125287 Human Kpna2 ORF clone (NM_010655.3) Inquiry
CDCR282834 Human KPNA2 ORF Clone(NM_002266.2) Inquiry
CDCR380300 Rat Kpna2 ORF Clone(NM_053483.2) Inquiry
CDCS410716 Human KPNA2 ORF Clone (BC005978) Inquiry
CDCS410717 Human KPNA2 ORF Clone (BC053343) Inquiry
CDCS410718 Human KPNA2 ORF Clone (BC067848) Inquiry
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