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KNG1


Official Full Name
kininogen 1
Organism
Homo sapiens
Gene ID
3827
Background
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]
Synonyms
BK; HK; BDK; KNG; HAE6; HMWK

Cat.No. Product Name Price
SHH326955 shRNA set against Human KNG1 (NM_000893.3) Inquiry
SHH326959 shRNA set against Mouse KNG1 (NM_023125.3) Inquiry
SHH326963 shRNA set against Rat KNG1 (NM_012696.2) Inquiry
SHL204006 shRNA set against Rat Kng1(NM_012696.2) Inquiry
SHL204102 shRNA set against Mouse Kng1(NM_023125.3) Inquiry
SHW007392 shRNA set against Danio rerio KNG1 (NM_001005981) Inquiry
Cat.No. Product Name Price
CDCL125271 Mouse Kng1 ORF clone (NM_001102411.1) Inquiry
CDFH010055 Human KNG1 cDNA Clone(NM_001166451.1) Inquiry
CDFR010510 Rat Kng1 cDNA Clone(NM_012696.2) Inquiry
MiUTR1M-06421 KNG1 miRNA 3'UTR clone Inquiry
MiUTR1R-02918 KNG1 miRNA 3'UTR clone Inquiry
MiUTR3H-12400 KNG1 miRNA 3'UTR clone Inquiry
MiUTR3H-12401 KNG1 miRNA 3'UTR clone Inquiry
CDCB168867 Danio rerio KNG1 ORF Clone (NM_001005981) Inquiry
CDCB195436 Rabbit KNG1 ORF clone (XM_008266577.1) Inquiry
CDCL125267 Human KNG1 ORF clone (NM_001166451.1) Inquiry
CDCL185073 Human KNG1 ORF clone(NM_001102416.2) Inquiry
CDCL185074 Mouse KNG1 ORF clone(NM_001102412.1) Inquiry
CDCR377557 Rat Kng1 ORF Clone(NM_012696.2) Inquiry
CDCS405979 Human KNG1 ORF Clone (BC060039) Inquiry
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