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KIR2DL5B


Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B
Organism
Homo sapiens
Gene ID
553128
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Synonyms
KIR2DL5; KIR2DLX; KIR2DL5.2

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SHL197830 shRNA set against Human KIR2DL5B(NM_001018081.1) Inquiry
SHL198136 shRNA set against Human KIR3DL1(NM_013289.2) Inquiry
SHL198172 shRNA set against Mouse Kir3dl1(NM_177749.3) Inquiry
SHL198264 shRNA set against Rat Kir3dl1(NM_181479.2) Inquiry
Cat.No. Product Name Price
CDFH009926 Human KIR2DL5B cDNA Clone(NM_001018081.1) Inquiry
CDFR014980 Rat Kir3dl1 cDNA Clone(NM_181479.2) Inquiry
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MiUTR1H-05334 KIR3DL1 miRNA 3'UTR clone Inquiry
MiUTR1H-05335 KIR3DL3 miRNA 3'UTR clone Inquiry
MiUTR1M-06327 KIR3DL1 miRNA 3'UTR clone Inquiry
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CDCB160179 Human KIR3DL1 ORF clone (BC028206) Inquiry
CDCL124407 Human KIR2DL5B ORF clone (NM_001018081.1) Inquiry
CDCL124423 Human KIR3DL1 ORF clone (NM_013289.2) Inquiry
CDCL151237 Human Kir3dl1 ORF clone (NM_177749.3) Inquiry
CDCL185037 Rat KIRC1 ORF clone(NM_001037441.1) Inquiry
CDCR005720 Human KIR3DL3 ORF clone(NM_153443.3) Inquiry
CDCR382027 Rat Kir3dl1 ORF Clone(NM_181479.2) Inquiry
CDCS413392 Human KIR3DL1 ORF Clone (BC028206) Inquiry
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