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KIR2DL4


Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Organism
Homo sapiens
Gene ID
3805
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
Synonyms
G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS

Cat.No. Product Name Price
SHL198030 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHH325491 shRNA set against Human KIR2DL4 (NM_002255.5) Inquiry
SHL198042 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198041 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198040 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198039 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198038 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198037 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198036 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198035 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198034 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198033 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198032 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL198031 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198029 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198018 shRNA set against Human KIR2DL4(NM_001080770.1) Inquiry
SHL197974 shRNA set against Human KIR2DL4(NM_001080772.1) Inquiry
SHL198043 shRNA set against Human KIR2DL4(NM_002255.5) Inquiry
SHL198090 shRNA set against Human KIR2DL4(NM_001080772.1) Inquiry
Cat.No. Product Name Price
CDCS407317 Human KIR2DL4 ORF Clone (BC041611) Inquiry
CDFH009923 Human KIR2DL4 cDNA Clone(NM_001080770.1) Inquiry
CDFH009924 Human KIR2DL4 cDNA Clone(NM_001080772.1) Inquiry
MiUTR1H-05324 KIR2DL4 miRNA 3'UTR clone Inquiry
MiUTR1H-05325 KIR2DL4 miRNA 3'UTR clone Inquiry
MiUTR1H-05326 KIR2DL4 miRNA 3'UTR clone Inquiry
CDCB182022 Rabbit HMCN2 ORF clone (XM_008252460.1) Inquiry
CDCL124399 Human KIR2DL4 ORF clone (NM_001080770.1) Inquiry
CDCL124401 Human KIR2DL4 ORF clone (NM_001080772.1) Inquiry
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