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jupa


Official Full Name
junction plakoglobin a
Organism
Danio rerio
Gene ID
30415
Background
Predicted to enable several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in Kupffer's vesicle development; adherens junction maintenance; and desmosome maintenance. Acts upstream of or within atrioventricular valve morphogenesis and negative regulation of Wnt signaling pathway. Located in several cellular components, including adherens junction; desmosome; and intercalated disc. Part of catenin complex. Is expressed in several structures, including EVL; ectoderm; forerunner cell group; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
jup; cb80; danPG; fb11b06; wu:fb11b06

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